SMU vs Louisville predictions, picks and odds

College football is back, and Doug Upstone from Vegas Pro Insiders Daily is giving OSGA fans, friends and members an edge every week of the 2026 NCAA Football season. Doug fires up a prediction for the SMU Mustangs at Louisville Cardinals game with odds from Bookmaker.eu.

Current Odds for Mustangs at Cardinals

SMU Mustangs (+1)
Louisville Cardinals (-1)
Total: 58.5 

SMU vs Louisville Time and How to Watch

Start time: 3:30 p.m. EDT
TV Channel: ESPN2
Livestream: Fubo, YouTube TV, DIRECTV, ESPN+

Doug's Free Pick

Given how the ACC looks, this is a massive matchup. I admit, I like this SMU team. Their offense is as good as anyone’s in the country. Louisville was super impressive at Ole Miss and could have easily won that game. The Cardinals at home helps them, but the point spread suggests SMU is the better squad. While revenge games don’t always work, losing 38-6 in Dallas has stuck with the Louisville players who were there. Also a concern, Florida State had no passing game to fear, and the Mustangs still allowed 199 yards rushing. That's a concern. Consider this system: Home teams like the Cardinals after gaining 525 or more total yards a contest over their last two games, in a skirmish between two teams with five or less defensive starters returning, in the first month of the season, have the homer 29-7 ATS. 

Play On: Louisville to win (-118)

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