NFL Week 16 Picks and Preview

The NFL Week 16 schedule is filled with major matchups, and it started Thursday night in Seattle. The Seahawks (12-3) overcame a 16 point 4th quarter deficit and just a 3% chance to win to stun the LA Rams (11-4) in overtime 38-37 with a successful 2-point completing the game of the year. 

Five more major matchups Saturday and Sunday include key division contests and other key games impacting teams playoff hopes and positions. The favorite has flipped in the Packers-Bears big first place NFC North division duel.  

Top Major Matchups

- Green Bay at Chicago (-1.5), Total 46.5 (Sat)
- Tampa Bay (-3) at Carolina, 45
- Jacksonville at Denver (-3.5), 47.5
- Pittsburgh at Detroit (-7), 52
- New England at Baltimore (-3), 49 - SNF

NFL Week 16 Odds

Betting lines and NFL odds from BetOnline and top online sportsbooks refresh periodically and are subject to change, including on props and live/in-game betting. Point spread on favorites and division games in bold. 

- Los Angeles Rams (-1) at Seattle, 44  - Thurs, Seahawks win 38-37 OT
- Philadelphia (-7) at Washington, 44 - Sat.
- Buffalo (-10.5) at Cleveland, 41.5
- New York Jets at New Orleans (-6.5), 40.5
- Minnesota (-2.5) at New York Giants, 43
- Kansas City (-3) at Tennessee, 37.5
- Los Angeles Chargers at Dallas (-2), 50
- Cincinnati (-4) at Miami, 47.5
- Atlanta (-2.5) at Arizona, 48.5
- Las Vegas at Houston (-14), 38.5
- San Francisco (-6) at Indianapolis, 46.5 - MNF

Notable line moves Saints -4.5 to -6.5 and Bengals -1.5 to -4 with QB Quinn Ewers making his starting debut for the Dolphins. 

Check out more Week 16 injury reports, and monitor the NFL weather with freezing temperatures near 12 degrees in Chicago and also cold (20-30 degrees) in Cincinnati, Kansas City, New England and Pittsburgh on Monday night. 

NFL Week 16 Picks

- Picks: Giants
- Opinions: Browns, Panthers, Chargers 

3-team parlay: Browns
2-team 'Dog parlay: Giants, Panthers

Game analysis and additional NFL news and information you can bet on for some of these Week 16 contests posted on another site through BetOnline. I'll add here as BOL posts. 

Picks are 7-2 ATS since Week 11. Opinions no good last week and knew I had the wrong side Browns on the road at Chicago with bumbling QB Sanders. The Patriots also blew a 21-0 lead in losing to the Bills, despite New England rushing for 246 yards, which is an issue for the Bills and plays into this week's pick on the Browns. Buffalo off that big comeback effort and division win and also Super Bowl champions Philadelphia Eagles on deck next week. As a big home 'Dog this week with better defense, we'll hope Sanders doesn't sh*t the bed or turn ball over too much.

Home 'Dogs on our card this week, knowing we hit 57% ATS posting NFL underdog picks only at OSGA from 2017-2023. Still considering the Patriots as 'Dog at Baltimore on Sunday Night Football. But no more excuses for Lamar Jackson and all the experience he and the Ravens have in these games as a perennial playoff contender (who has never made the AFC Championship Game), and Ravens are now on the outside looking in at the playoffs with 3 games to go. 

Bet on NFL Player Props at one of these Elite-rated sportsbooks!

NFL Player Props

Broncos WR Courtland Sutton - Over 58.5 receiving yards 

Check back Sunday for any additional player props. 

You can bet on it. 

FairwayJay is a proven sports handicapper with top of the leaderboard success in NFL pointspread prognosis. Fairway is recognized as one of the sports industry's insightful analysts, and he chips in additional sports betting coverage and reporting on industry news and events. Follow FairwayJay here at OSGA.com and on X @FairwayJay for more sports betting insights.